Skip to main content
. 2013 Jan 17;7(1):e2005. doi: 10.1371/journal.pntd.0002005

Figure 1. Bispidine and its derivatives.

Figure 1

(A) Structural relationship of bispidine to natural product sparteine. (B) General structure of bispidine compounds (i) and (ii) represent the conformer equilibrium in diimides of bispidine (iii) Conjugates of bispidine wherein the nitrogen is part of the amino acids. (C) The genesis of design of bispidine. (D) Synthesis of bispidine conjugates i) N-hydroxysuccinimide/DCC/NEt3/Boc-Leu-OH/dry dichloromethane; ii) N-hydroxysuccinimide/DCC/NEt3/Z-Leu-OH/dry dichloromethane; iii) Br-CH2-CO-Leu-Val-OMe; NEt3, acetonitrile; iv) 25% TFA in dichloromethane.