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. 2013 Jan 17;8(1):e54208. doi: 10.1371/journal.pone.0054208

Figure 5. Effect of S107 on the stability of FKBP12-RyR1 complex in skeletal muscle homogenates.

Figure 5

(A and B) Skeletal muscle homogenates were incubated without (control) or with 5 mM GSH, 5 mM GSSG or 0.10 mM NOC12 in the absence or presence of 44 µM S107 for 20 h at 24°C. Unbound FKBP12 was removed by centrifugation and the amounts of RyR1 and FKBP12 were detected using anti-RyR1 and anti-FKBP12 antibodies. Homogenates incubated without glutathione and NOC12 served as control. Data are the mean ± SEM of 8 experiments. *p<0.05 compared to control homogenates without S107. #p<0.05 compared to homogenates incubated with NOC12 in the absence of S107.