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Figure 1. Schematic representation of the structure of Rho-GEFs Trio and Kalirin. Trio and Kalirin both express two DH-PH units (green/red) and a serine-kinase domain (yellow). Both DH-PH units are flanked by a SH3 domain (lime/rose). Trio and Kalirin harbor a SEC14 domain (royal blue) and spectrin-repeats (sky blue) at the N-terminus.
