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Figure 1. Potential complexes of VEGF and SEMA class 3 with NRPs. Electronegative charges in the B domain interact with both basic region in C and exon 7/8 domains of Sema 3 and VEGF, respectively. Semaphorins class 3 also interact with the a1/a2 domain via the Sema 3 and Ig sequences. The MAM domain induces oligomerization that is important to induce biological activities of both Sema and VEGF.
