Figure 7. miR-22 decreases caspase activation preceding neuronal cell death.

miR-22 was assessed for its effects on caspase 3/7 activities in primary striatal neurons in the following neurodegenerative conditions: A) expressing a fragment of mutant Htt (Htt82Q), B) treated with 150 µM 3-NP or C) long-term culture (to model aging). The miR-22-overexpressing condition is compared to the control with no miRNA overexpression (see text for rationale). Graphs represent mean ± SEM, ** represents p-value <0.01, by unpaired t-test, CTRL – non-infected cells.