Figure 5. Loss of apoE exacerbates axonal injury after mrTBI.

Axonal damage following mrTBI was assessed with silver staining (arrows). The left panel depicts representative images of silver-stained coronal sections at approximately −1.58 mm from bregma [66] of untreated WT (A) and apoE−/− (B) mouse brains harvested at 7 d post-mrTBI. White matter areas with prominent silver staining are indicated by the black squares. Injury location is indicated by the arrowhead. The right panel (C–L) depicts representative 40x-magnified images of silver staining in five white matter areas in the brains of untreated WT (C–G) and apoE−/− (H–L) mice harvested at 7 d post-mrTBI.