Table 1. Genotype and allele frequencies of common variants detected in ASMT between patients with autism and healthy controls.
| Marker | Genotype and frequency | χ2 (df = 2) | P | Allele and frequency | χ2 (df = 1) | P | OR (95%CI) | |||
| Promoter and exon 1 | ||||||||||
| rs4446909 | GG | AG | AA | G | A | |||||
| patients | 199 (0.500) | 161 (0.405) | 38 (0.095) | 3.015 | 0.221 | 559 (0.702) | 237 (0.298) | 0.950 | 0.330 | 1.109 |
| controls | 194 (0.448) | 201 (0.464) | 38 (0.088) | 589 (0.680) | 277 (0.320) | (0.900–1.366) | ||||
| rs5989681 | GG | CG | CC | G | C | |||||
| patients | 128 (0.326) | 193 (0.491) | 72 (0.183) | 2.687 | 0.261 | 449 (0.571) | 337 (0.429) | 1.729 | 0.188 | 1.139 |
| controls | 119 (0.274) | 231 (0.531) | 85 (0.195) | 469 (0.539) | 401 (0.461) | (0.938–1.383) | ||||
| rs6644635 | CC | CT | TT | C | T | |||||
| patients | 232 (0.584) | 147 (0.370) | 18 (0.046) | 0.485 | 0.785 | 611 (0.770) | 183 (0.230) | 0.020 | 0.887 | 1.017 |
| controls | 257 (0.588) | 156 (0.357) | 24 (0.055) | 670 (0.767) | 204 (0.233) | (0.810–1.277) | ||||
| Intron 5 | ||||||||||
| rs28675287 | TT | CT | CC | T | C | |||||
| patients | 147 (0.375) | 187 (0.477) | 58 (0.148) | 1.719 | 0.423 | 481 (0.614) | 303 (0.386) | 0.752 | 0.386 | 1.091 |
| controls | 144 (0.333) | 224 (0.519) | 64 (0.148) | 512 (0.593) | 352 (0.407) | (0.896–1.330) | ||||
| Exon 6 | ||||||||||
| rs6588809a | TT | CT | CC | T | C | |||||
| patients | 105 (0.276) | 185 (0.487) | 90 (0.237) | 4.052 | 0.132 | 395 (0.520) | 365 (0.480) | 0.692 | 0.405 | 0.920 |
| controls | 91 (0.222) | 226 (0.553) | 92 (0.225) | 408 (0.499) | 410 (0.501) | (0.755–1.120) | ||||
| Intron 6 | ||||||||||
| rs28613362 | AA | AG | GG | A | G | |||||
| patients | 225 (0.581) | 137 (0.354) | 25 (0.065) | 0.961 | 0.618 | 587 (0.758) | 187 (0.242) | 0.698 | 0.403 | 0.906 |
| controls | 255 (0.601) | 148 (0.349) | 21 (0.050) | 658 (0.776) | 190 (0.224) | (0.720–1.141) | ||||
| Intron 8 | ||||||||||
| rs11346829 | GG | G/del | del/del | G | del | |||||
| patients | 346 (0.880) | 47 (0.120) | 0 | 3.167 | 0.273b | 739 (0.940) | 47 (0.060) | 0.002 | 0.966 | 0.991 |
| controls | 382 (0.888) | 45 (0.105) | 3 (0.007) | 809 (0.941) | 51 (0.059) | (0.659–1.492) | ||||
a
, Hardy-weinberg Equilibrium P value less than 0.05 in healthy controls;
b
, Monte Carlo significance (2-sided). OR, odds ratio; CI, confidence interval; del, deletion.