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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Traffic. 2012 Sep 13;14(1):2–14. doi: 10.1111/tra.12004

Figure 1. mRNA-binding proteins couple mRNAs to molecular motors for active transport.

Figure 1

A, Yeast mRNA-binding protein She2p in a complex with She3p recruits myosin (Myo4/She1p) onto Ash1 mRNA. B, Drosophila non-canonical RNA-binding protein, Egl1, and Bic-D interact with dynein and dynactin complexes, respectively, to couple TLS-containing mRNAs to dynein for microtubule minus-end directed mRNA transport. C, FMRP facilitates the localization of its target mRNAs to dendritic compartments in mammalian neurons in response gp1 mGluR activation. FMRP may directly (left) or indirectly (right) interact with kinesin light chain (KLC) to couple mRNAs to conventional kinesin motors for mRNA localization.