Table 2.
Summary of patients treated with non-concordant neurostimulation
| Report | Dx | No Perm | Resp Rate | Notes |
|---|---|---|---|---|
| Cluster Treated with ONS Alone | ||||
| Dodick [28••] | Cl | 1 | 100 % | HA free after 12 mo |
| Burns [68, 69] | Cl, HC | 20 | 45 % | 9 of 20 had >50 % imp |
| Magis [32] | Cl | 14 | 85 % | 80 % had >90 % imp |
| Trentman [38] | Cl | 5 | 60 % | 3 had fair to exc resp |
| Schwedt [35] | Cl | 8 | 60 % | 60 % had >50 % imp |
| de Quintana [29] | Cl | 4 | 100 % | All had >50 % imp |
| Fontaine [30] | Cl | 13 | 77 % | 77 % had >50 % imp |
| Mueller [34] | Cl | 10 | 40 % | All had >50 % imp in freq/sev |
| 62 % avg | ||||
| Chronic Migraine Headaches Treated with ONS Alone | ||||
| Saper (Medtronic) [42••] | CM | 51 | 39 % | 39 % had > 30 % VAS imp |
| Silberstein (St. Jude) [41••] | CM | 105 | 35 % | 35 % had > 30 % VAS imp |
| Lipton (Boston Sc) [40•] | CM | 132 | ? | Statistical results not significant |
| Pameliere [19•] | MWA | 8 | 63 % | 47 % average relief |
| Serra [39] | CM | 29 | 100 % | MIDAS, SF36, meds all stat sig |
| 48 % avg | ||||
| Summary: | 48 % average response rate (> 50 % VAS imp) for all chronic migraine studies | |||
| 37 % average response rate (> 30 % VAS imp) for the “benchmark” Medtronic and St. Jude studies | ||||
Cl cluster; CM chronic migraine; HC hemicranias continua; MWA migraine without aura