Table 2.
Pharmacokinetic variables for buprenorphine and norbuprenorphine (FAS)
| Variable | Statistic | Buprenorphine | Norbuprenorphine | ||
|---|---|---|---|---|---|
| Younger (n = 36) | Elderly (n = 36) | Younger (n = 36) | Elderly (n = 36) | ||
| AUCtau (pg/h/ml) | No. of observations | 36 | 36 | 36 | 36 |
| Mean (SD) | 11,309.33 (3,669.51) | 9,939.87 (4827.13) | 2,922.00 (1338.08) | 3,063.23 (1,771.45) | |
| Min, max | 2,421.6, 22464.0 | 2,100.0, 19842.0 | 2,100.0, 6631.2 | 2,100.0, 7669.2 | |
| Cmaxss (pg/ml) | No. of observations | 36 | 36 | 36 | 36 |
| Mean (SD) | 83.46 (28.97) | 72.15 (34.79) | 21.73 (12.48) | 20.46 (13.17) | |
| Min, Max | 25.9, 169.0 | 12.5, 153.0 | 12.5, 50.0 | 12.5, 56.5 | |
| Cminss (pg/ml) | No. of observations | 36 | 36 | 36 | 36 |
| Mean (SD) | 47.71 (18.17) | 47.45 (22.89) | 13.85 (4.59) | 16.33 (8.21) | |
| Min, max | 12.5, 110.0 | 12.5, 93.9 | 12.5, 31.7 | 12.5, 42.7 | |
| Fluctuation index | No. of observations | 36 | 36 | 36 | 36 |
| Mean (SD) | 1.89 (0.72) | 1.61 (0.73) | 1.57 (0.82) | 1.22 (0.45) | |
| Min, max | 1.2, 4.3 | 1.0, 5.3 | 1.0, 3.5 | 1.0, 2.6 | |
FAS full analysis set, AUC tau area under the plasma concentration-time curve at steady state, C maxss maximum observed plasma concentration measured over one dosing interval at steady state , C minss minimum observed plasma concentration measured over one dosing interval at steady state, SD standard deviation, Min, max minimum, maximum