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. 2012 Jun 17;69(2):143–149. doi: 10.1007/s00228-012-1320-8

Table 2.

Pharmacokinetic variables for buprenorphine and norbuprenorphine (FAS)

Variable Statistic Buprenorphine Norbuprenorphine
Younger (n = 36) Elderly (n = 36) Younger (n = 36) Elderly (n = 36)
AUCtau (pg/h/ml) No. of observations 36 36 36 36
Mean (SD) 11,309.33 (3,669.51) 9,939.87 (4827.13) 2,922.00 (1338.08) 3,063.23 (1,771.45)
Min, max 2,421.6, 22464.0 2,100.0, 19842.0 2,100.0, 6631.2 2,100.0, 7669.2
Cmaxss (pg/ml) No. of observations 36 36 36 36
Mean (SD) 83.46 (28.97) 72.15 (34.79) 21.73 (12.48) 20.46 (13.17)
Min, Max 25.9, 169.0 12.5, 153.0 12.5, 50.0 12.5, 56.5
Cminss (pg/ml) No. of observations 36 36 36 36
Mean (SD) 47.71 (18.17) 47.45 (22.89) 13.85 (4.59) 16.33 (8.21)
Min, max 12.5, 110.0 12.5, 93.9 12.5, 31.7 12.5, 42.7
Fluctuation index No. of observations 36 36 36 36
Mean (SD) 1.89 (0.72) 1.61 (0.73) 1.57 (0.82) 1.22 (0.45)
Min, max 1.2, 4.3 1.0, 5.3 1.0, 3.5 1.0, 2.6

FAS full analysis set, AUC tau area under the plasma concentration-time curve at steady state, C maxss maximum observed plasma concentration measured over one dosing interval at steady state , C minss minimum observed plasma concentration measured over one dosing interval at steady state, SD standard deviation, Min, max minimum, maximum