Table 2.
Buprenorphine pharmacokinetics (mean ± 1 SD) after a single injection of LDB, HDB, or SRB in macaques
| Parameter | LDB | HDB | SRB |
| Cmax (ng/mL) | 8.1 ± 7.7 | 40.7 ± 48.7 | 15.3 ± 19.1 |
| Tmax (h) | 0.5 ± 0.3 | 0.5 ± 0.5 | 9.3 ± 10.8 |
| Tlast (h) | 10.8 ± 4.5 | 20.8 ± 3.7 | 120a |
| λz (1/h) | 0.28 ± 0.07 | 0.15 ± 0.05 | 0.02 ± 0.01 |
| t1/2 (h) | 2.6 ± 0.7 | 5.3 ± 2.0 | 42.6 ± 26.2 |
| AUC0-Tlast (ng×h/mL) | 9.1 ± 4.3 | 39.0 ± 25.1 | 177.0 ± 74.0 |
| AUC0-∞ (ng×h/mL) | 9.3 ± 4.0 | 40.4 ± 25.3 | 180.0 ± 55.4 |
| MRT (h) | 2.5 ± 1.0 | 3.4 ± 1.2 | 40.1 ± 7.4 |
| V (L/kg) | 4.5 ± 1.5 | 3.4 ± 4.4 | 74.8 ± 48.6 |
| Clearance (L/h/kg) | 1.3 ± 0.6 | 0.4 ± 0.5 | 1.2 ± 0.3 |
For most parameters, n = 10 macaques; for λz, t1/2, AUC0-∞, MRT, V, and clearance, n = 8 for LDB and n = 7 for SRB.
a
The last sample collection occurred at 120 h, and all macaques had measurable plasma concentrations. This value therefore would have been greater had sample collection been extended beyond this point.