Table 3.
Norbuprenorphine pharmacokinetics (mean ± 1 SD) after a single injection of LDB, HDB, or SRB in macaques
| Parameters | LDB | HDB | SRB |
| Cmax (ng/mL) | 0.9 ± 0.7 | 4.0 ± 4.0 | 1.6 ± 2.1 |
| Tmax (h) | 1.1 ± 1.7 | 0.4 ± 0.1 | 9.8 ± 10.5 |
| Tlast (h) | 15.6 ± 7.1 | 16.2 ± 5.8 | 105.6 ± 16.8 |
| λz (1/h) | — | 0.15 ± 0.00 | 0.02 ± 0.01 |
| t1/2 (h) | — | 4.5 ± 0.1 | 49.2 ± 29.4 |
| AUC0-Tlast (ng×h/mL) | 3.3 ± 1.8 | 5.1 ± 1.8 | 26.2 ± 14.6 |
| AUC0-∞ (ng×h/mL) | — | 4.9 ± 0.7 | 43.0 ± 8.1 |
| MRT (h) | — | 3.9 ± 0.2 | 44.1 ± 8.8 |
| V (L/kg) | — | 15.6 ± 27.0 | 84.2 ± 119.1 |
| Clearance (L/h/kg) | — | 2.4 ± 4.2 | 2.0 ± 2.9 |
For most parameters, n = 10; for λz, t1/2, AUC0-∞, MRT, V, and clearance, n = 2 for both HDB and SRB.