Table 4.
Buprenorphine-3-glucuronide pharmacokinetics (mean ± 1 SD) after a single injection of LDB, HDB, or SRB in macaques
| Parameters | LDB | HDB | SRB |
| Cmax (ng/mL) | 0.4 ± 0.3 | 0.7 ± 0.6 | 0.6 ± 0.7 |
| Tmax (h) | 4.5 ± 7.4 | 2.0 ± 3.8 | 26.4 ± 25.7 |
| Tlast (h) | 6.2 ± 8.7 | 17.3 ± 6.0 | 62.7 ± 27.3 |
| λz (1/h) | — | — | 0.03 ± 0.01 |
| t1/2 (h) | — | — | 24.7 ± 8.9 |
| AUC0-Tlast (ng×h/mL) | 2.5 ± 5.7 | 3.9 ± 2.0 | 28.9 ± 52.2 |
| AUC0-∞ (ng×h/mL) | — | — | 19.9 ± 7.5 |
| MRT (h) | — | — | 26.8 ± 10.6 |
| V (L/kg) | — | — | 364.0 ± 56.7 |
| Clearance (L/h/kg) | — | — | 11.2 ± 4.9 |
For most parameters, n = 10; for λz, t1/2, AUC0-∞, MRT, V, and clearance of SRB, n = 3.