Table 1.
Macaque | Weight (kg) | Mobilizing agent(s) | Dose(s) | Blood volume given before leukapharesis (mL) | Duration of procedure (min) | No. of CD34+ cells recovered (× 106) | Total no. of cells (× 109) | No. of PBMC per kg of donor weight (× 108) | Total volume collected (mL) |
S0109 | 5.2 | GCSF | 10 μg/kg | 125 | 240 | — | 6.5 | 12 | 30 |
S0509 | 5.3 | GCSF | 10 μg/kg | 130 | 240 | 1.86 | 2.24 | 4.2 | 62 |
S0309A | 8.1 | GCSF | 10 μg/kg | 194 | 240 | — | 1.5 | 1.9 | 60 |
S0309B | 8.8 | GCSF | 100 μg/kg | 210 | 260 | — | 4.8 | 5.4 | 30 |
S9010 | 4.7 | G-CSF | 100 μg/kg | 110 | 280 | 1.41 | 1.5 | 3.2 | 69 |
S0510 | 5.3 | GCSF + AMD 3465 | 100 μg/kg, 1mg/kg | 127 | 240 | 5.16 | 2.0 | 3.7 | 62 |
S0910 | 4.0 | GCSF + AMD 3465 | 100 μg/kg, 1 mg/kg | 96 | 275 | — | 1.7 | 4.2 | 85 |
S8810 | 3.9 | GCSF + AMD 3465 | 100 μg/kg, 1 mg/kg | 90 | 300 | 1.19 | 2.0 | 5.1 | 48 |
S8610 | 5.4 | GCSF + AMD 3465 | 100 μg/kg, 1 mg/kg | 129 | 300 | — | 1.5 | 2.7 | 57 |
There were no significant differences between treatment groups in the total number of cytokine-mobilized PBMC recovered.