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. 2011 Jul 1;1(1):66–75. doi: 10.4161/biom.1.1.16277

Figure 4.

Figure 4.

Effects of PLG vaccination on cells in draining lymph nodes (A and B) The number of phagocytic cells: CD11b(+)CD11c(-) macrophages, CD11c(+) DCs, and PDCA-1(+)CD11c(+) plasmacytoid DCs, in the draining inguinal lymph nodes of mice at (A) day 3 and at (B) day 10 after implantation of blank matrices (Blank) or PLG matrices containing GM-CSF and Lysate (GMCSF+LYS) only or PLG vaccines (GMCSF+Lys+CpG). (C) The number of T cells: CD3(+) T cells, CD3(+)CD8(+) T cells, and CD3(+)CD4(+) T cells, in the draining inguinal lymph nodes of mice at day 10 after implantation of blank matrices (Blank) or PLG matrices containing GM-CSF and Lysate (GMCSF+LYS) only or with CpG-ODN (GMCSF+Lys+CpG). (D) The number of CD3(+)FoxP3(+) Tregs in the draining inguinal lymph nodes of mice at day 16 after implantation of blank matrices (Blank) or PLG matrices containing GM-CSF and Lysate (GMCSF+LYS) only or with CpG-ODN (GMCSF+Lys+CpG). (E) The ratio of CD8 T cells vs. CD3(+)FoxP3(+) Tregs in the draining inguinal lymph nodes of mice at day 16 after implantation of PLG matrices containing GM-CSF and Lysate (GMCSF+LYS) only or with CpG-ODN (GMCSF+Lys+CpG). Values represent mean and standard deviation (n = 4 or 5). *p < 0.05** p < 0.01 as compared with controls.