Table 1. Diseases that require pulsatile drug delivery.

Disease	Chronological behavior	Drugs used
Peptic ulcer	Acid secretion is high in the afternoon and at night.	H2blockers
Cancer	The blood flow to tumors is 3-fold greater during each daily activity phase of the circadian cycle than during the daily rest phase.	Vinca alkaloids, Taxanes
Duodenal ulcer	Gastric acid secretion is highest at night while gastric and small bowel motility and gastric emptying are all slower at night.	Proton pump inhibitors
Neurological disorders	The central pathophysiology of epilepsy and the behavioral classification of convulsive events.	MAO-B inhibitor
Hypercholesterolemia	Cholesterol synthesis is generally higher during night than day time.	HMG CoA reductase Inhibitors
Diabetes mellitus	Increase in the blood sugar level after meal.	Sulfonylurea, Insulin
Arthritis	Level of pain increases at night.	NSAIDs, Glucocorticoids
Cardiovascular diseases	BP is at its lowest during the sleep cycle and rises steeply during the early morning.	Nitroglycerin, calcium channel blocker, ACE inhibitors
Asthma	Precipitation of attacks during night or at early morning.	Β2 agonist, Antihistamines
Attention deficit syndrome	Increase in DOPA level in afternoon.	Methylphenidate