Figure 1.
Power of 12 statistics: the SFPCA (discretization approach) statistic, SFPCA (Fourier expansion approach) statistic, FPCA (discretization approach)-based statistics, FPCA (Fourier expansion approach)-based statistic, SKAT, multivariate PC-based statistic, WSS, VT, collapsing method, generalized T2 statistic, single marker χ2 test and CMC method (the variants with frequencies ≤0.005 were collapsed) as a function of the proportion of risk increasing variants for testing the association of 180 rare variants at significance level α=0.05 with the disease under the additive disease model, assuming baseline penetrance of 0.01 and 2000 cases and 2000 controls.