Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Hypothetical binding mode of inhibitor 13a in the Ag85C active site predicted using Glide 4.5. The arabinofuranoside substituent is located in the trehalose binding pocket and the ester moiety is oriented in the vicinity of Ser124. The tetrahydrobenzo[b]thiopene is accommodated in the mycolate α-chain binding channel extending through the core of Ag85C.
