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. Author manuscript; available in PMC: 2013 Jan 18.

Published in final edited form as: Adv Mater. 2011 Aug 15;23(36):H248–H253. doi: 10.1002/adma.201101877

Biodistribution of nanoparticles quantified 24 h post-injection into HCC tumor burdened Sprague Dawley rats. Results of ICP-OES analysis for (A) Si and (B) Fe on the indicated organs. Formulations “pSi,” “Fe₃O₄” and “25% NC” correspond to empty poly(ethylene) glycol-coated Si nanoparticles, Fe₃O₄ nanoparticles encapsulated in 2 kDa poly(ethylene) glycol micelles, and composite nanoparticles (Fe₃O₄:pSi mass ratio = 25%), respectively. The in vivo residence time of the three formulations, obtained from blood samples using fluorescently labeled (Cy-7) nanoparticles, is quantified in (C). The half-life of the nanocomposite particles was 96 min.

Biodistribution of nanoparticles quantified 24 h post-injection into HCC tumor burdened Sprague Dawley rats. Results of ICP-OES analysis for (A) Si and (B) Fe on the indicated organs. Formulations “pSi,” “Fe₃O₄” and “25% NC” correspond to empty poly(ethylene) glycol-coated Si nanoparticles, Fe₃O₄ nanoparticles encapsulated in 2 kDa poly(ethylene) glycol micelles, and composite nanoparticles (Fe₃O₄:pSi mass ratio = 25%), respectively. The in vivo residence time of the three formulations, obtained from blood samples using fluorescently labeled (Cy-7) nanoparticles, is quantified in (C). The half-life of the nanocomposite particles was 96 min.