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. 2010 Mar 10;30(10):3555–3566. doi: 10.1523/JNEUROSCI.4551-09.2010

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Copyright © 2010 the authors 0270-6474/10/303555-12$15.00/0

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Figure 8. — A, B, Activity-dependent reduction in number of mobile mitochondria is Na/K-ATPase dependent. Relative changes in the number of mobile mitochondria before [control (Cont)] and during repetitive stimulation (2 min; 200 Hz). Nerves were stimulated either in normal Ringer's solution or in two modified Ringer's solutions designed to block Na/K-ATPase but preserve action potentials [lithium replacing all bath Na (N = 6 nodes) or 0.5 mm ouabain (Ouab) in Ringer's solution (N = 6 nodes)]. Note that blocking Na/K-ATPase completely blocks activity-dependent reduction in the number of mobile mitochondria. **p < 0.01. Error bars indicate SEM.