Figure 3.

Salubrinal reduces ER/M accumulation of αS pathology. A, ER/M fractions from Salubrinal (Sal)-treated A53T αS mice were dot-blotted for αS oligomers (A11, FILA-1). B, The graphs showing the quantitative analysis of the dot-blots, which show significant decreases in αS oligomers with the Salubrinal treatment. The values were normalized either for total protein (FILA-1, A11) or for total αS (FILA-1/αS, A11/αS) followed by the average of vehicle (Veh) group. Values are given as the mean ± SEM (n = 3). ***p < 0.001, **p < 0.01, *p < 0.05, Student's t test.