Figure 5.

Genetic ablation of AR exacerbates intermediate lesions. Eight week old AR^−/−/apoE^−/− and AR^+/+/apoE^−/− mice were maintained on a high-fat diet for 12 weeks (Protocol IV). Lesion formation in male mice was examined in the aortic sinus (A), the aortic arch (B) and abdominal aorta (C). Panels D–F show lesion formation in the aortic sinus, the aortic arch, and the abdominal aorta respectively of female mice. Values are mean ± SEM. *P < 0.01 and ^# P<0.02 versus controls.