FIGURE 5.

A PPARα ligand prevents LPS-mediated up-regulation of C3 gene in mouse liver. Mice were intravenously injected with LPS, WY-14643 (WY), or DMSO (control), and the level of C3 expression in the liver 24 h after treatment was determined, and β-actin was normalized by real time RT-PCR. The levels of C3 expression in each mouse liver and median are shown. The statistical analyses of differences between compared groups versus control group were performed using Kruskal-Wallis Dunn's multiple comparison test (*, p < 0.05). N.S., not significant.