TABLE 1.

Conserved serine in calnuc among various organisms

Conserved serine, histidine, and aspartic acid residues can be observed on the basis of the multiple sequence alignment (MSA) of calnuc from a variety of organisms. Residues forming the serine protease active site in calnuc among the different species are denoted. A, the Ser-224 residue although highly conserved among all of them except in Drosophila melanogaster may not be involved in the catalysis. B, Ser-378, Asp-238, and His-339 form the catalytic triad of the active site.