FIGURE 4.

Differences in deuterium exchange rates for GIVA cPLA₂ upon binding to two lipophilic inhibitors. Time-dependent H/D exchange rates (HDX) in the presence and absence of the inhibitors pyrrophenone (A) and 2-oxoamide AX007 (B) are shown mapped onto the resulting molecular dynamics simulation of the structural model of GIVA cPLA₂ (Protein Data Bank code 1CJY). The decreases/increases in the exchange rates are color-coded as shown in the legend (from Ref. 20).