FIGURE 1.

Structural alignments of hamster α_1B-AR, human β₁-AR (PDB code 2VT4), human β₂-AR (PDB code 2RH1), human M₂-AR (PDB code 3UON), and rat M₃-AR (PDB code 4DAJ). The three-dimensional structural alignments were performed using program TOPOFIT (55) with a joint distance cutoff of 3 Å between the Cα atoms of the residues in the α_1B-AR model and each crystal structure. The alignment represents the degree of conservation of residues spatially. The poorly aligned regions indicate residues are not topologically close, although the sequence may be conserved.