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Distinct angiogenic cues regulate arterial and venous angiogenesis during early zebrafish development. VEGFA regulates sprouting from the Dorsal Aorta, while BMP signaling is the predominate angiogenic cue during venous angiogenesis off the Axial Vein. VEGFA expressed dorsally within somites attracts sprouts from the Dorsal Aorta. Meanwhile, ventral expression of BMP regulates sprouting from the axial vein.
