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. 2012 Dec 21;15(2):198–207. doi: 10.1093/neuonc/nos302

Fig. 2.

Fig. 2.

Cucurbitacin-I and WP1066 dramatically inhibit growth of BTSCs with diverse mutational profiles. (A and B) Cucurbitacin-I and WP1066 reduced cell viability in BTSC30 and -73 in a dose-dependent manner. (C) Cucurbitacin-I and WP1066 dramatically reduced alamarBlue conversion in all BTSC lines but not human fetal astrocytes (HF Astros) (* denotes P < .01 vs DMSO, Tukey's multiple comparison test). (D) Cucurbitacin-I and WP1066 completely abolished sphere formation in both BTSC30 and -73 (* denotes P < .01 vs DMSO, Tukey's multiple comparison test). Abbreviations: wt, wild type; mt, mutation; vIII, variant III.