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. 2012 Dec 21;15(2):198–207. doi: 10.1093/neuonc/nos302

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© The Author(s) 2012. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

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Fig. 4. — STAT3 shRNA knockdown decreases BTSC sphere growth. (A) Transduction of BTSCs with lentiviruses expressing 2 different shRNA sequences targeted against STAT3 dramatically reduced the levels of STAT3 protein after 6 days compared with nontargeting shRNA or untransduced control BTSCs. (B and C) STAT3 shRNA cultures generated significantly fewer spheres compared with corresponding nontargeting shRNA or untransduced control BTSCs (P < .05, Tukey's multiple comparison test). Abbreviation: n.s., nonsignificant.