Table 3.

Supermodules and GO Processes

GO Biological Processes	A	Adj p-value	B	Adj p-value	C	Adj p-value	D	Adj p-value
Anti -apoptosis	□		■	2.75E-04	■	2.02E-04	□
Apoptosis	□		■	5.44E-05	■	4.28E-05	□
Calcium ion homeostasis	■	2.54E-05	■	5.05E-05	■	4.14E-05	□
Cell cycle arrest	□		■	1.72E-04	■	1.28E-04	■	4.51E-05
Cell growth and/or maintenance	□		■	0.0017627	■	0.0013941	□
Cell proliferation	□		■	0.002006	■	0.0016282	□
Cellular defense response	■	1.91E-04	■	7.28E-05	■	4.00E-05	□
Circadian rhythm	■	1.51E-05	■	3.74E-05	□		□
DNA repair	□				□		■	1.06E-04
Embryogenesis and morphogenesis	■	2.66E-04	■	6.27E-04	■	4.51E-04	□
Immune response	■	9.17E-05	■	0.0024494	■	1.38E-04	□
Inflammatory response	■	2.98E-04	■	7.62E-04	■	5.47E-04	□
Intracellular signaling cascade	□		■	0.00237	■	0.0019023	□
Lipid metabolism	□		□		□		■	9.66E-05
Positive regulation of cell proliferation	□		□		□		■	1.10E-04
Protein biosynthesis	□		□		□		■	1.30E-04
Regulation of CDK activity	□		□		□		■	3.01E-05
Regulation of transcription DNA-dependent	■	0.0057307	■	0.0019621	□		■	0.0027668
Regulation of transcription from Pol II promoter	□		■	0.0011795	□		□
Response to DNA damage stimulus	□		■	2.81E-05	■	2.46E-05	□
Response to oxidative stress	■	3.78E-05	■	6.04E-05	■	5.05E-05	□
Response to viruses	■	3.01E-05	■	5.60E-05	■	4.90E-05	□
Rho protein signal transduction	□		■	5.38E-05	■	4.59E-05	□
Signal transduction	■	9.32E-05	■	0.0022916	■	0.0017359	■	1.49E-05
Small GTPase mediated signal transduction	■	2.88E-04	□		□		■	1.16E-04

The table summarizes GeneOntology biological process annotation for differentially expressed genes containing a supermodule in the 5’ upstream region. The ■ symbol denotes participation of the supermodule regulated gene in a biological process, and the □ symbol shows the absence of annotation for the regulated gene in a process. The adjusted p-values associated to the occurrence frequencies for each category/module are displayed on the right side adjacent of the corresponding module.