Table 4.

Supermodules and GO Functions

GO Molecular Function	A	Adj p-value	B	Adj p-value	C	Adj p-value	D	Adj p-value
Actin binding	■	2.93E-04	□		□		■	1.16E-04
Antiviral response protein activity	■	2.85E-05	■	4.72E-05	■	4.14E-05	□
Apoptosis inhibitor activity	□		■	1.18E-04	■	9.58E-05	□
Calmodulin binding	■	2.00E-04	□		□		■	1.02E-04
Chemokine activity	■	5.51E-05	■	9.11E-05	■	7.48E-05	□
GTPase inhibitor activity	■	2.54E-05	□		□		■	6.78E-06
Helicase activity	□		■	5.72E-05	□		□
Microtubule binding	□		■	4.30E-05	■	2.82E-05	□
Protein binding	■	0.00170446	□		■	2.58E-03	□
Ras GTPase activator activity	■	1.27E-05	□		□		■	3.39E-06
Rho GTPase activator activity	□		■		■	5.17E-05	□
Structural constituent of ribosome	□		□		□		■	9.72E-05
Transcription co-activator activity	□		■	9.39E-04	□		□
Transcription factor activity	■	0.0039627	■	0.00771924	□		□

The table summarizes GeneOntology molecular function annotation for differentially expressed genes containing a supermodule in the 5’ upstream region. The ■ symbol denotes the existence of annotation for a supermodule regulated gene with a molecular function, and the □ symbol shows the absence of annotation for a regulated gene with that function. The adjusted p-values associated to the occurrence frequencies for each category/module are displayed on the right side adjacent of the corresponding module