Table 3.
Ten most significant KEGG and GO categories enriched among the genes displaying alternative exon usage
| Source | Category | Gene Count1 | FDR P-value2 |
|---|---|---|---|
|
KEGG Pathway |
(hsa04510) focal adhesion |
86 |
3.2E-21 |
| (hsa04512) ecm-receptor interaction |
51 |
8.5E-20 |
|
| (hsa02010) abc transporters |
30 |
2.5E-12 |
|
| (hsa04810) regulation of actin cytoskeleton |
66 |
1.7E-07 |
|
| (hsa05412) arrhythmogenic right ventricular cardiomyopathy |
32 |
5.9E-06 |
|
| (hsa05414) dilated cardiomyopathy |
37 |
1.3E-06 |
|
| (hsa04070) phosphatidylinositol signaling system |
31 |
1.2E-05 |
|
| (hsa05222) small cell lung cancer |
31 |
3.6E-04 |
|
| (hsa05410) hypertrophic cardiomyopathy |
32 |
1.3E-04 |
|
| |
(hsa05200) pathways in cancer |
73 |
3.0E-02 |
|
GO Biological Process |
(GO:0051056) regulation of small GTPase mediated signal transduction |
105 |
0.055 |
| (GO:0022610) biological adhesion |
197 |
2.7E-22 |
|
| (GO:0007155) cell adhesion |
197 |
2.3E-22 |
|
| (GO:0046578) regulation of Ras protein signal transduction |
79 |
5.0E-15 |
|
| (GO:0035023) regulation of Rho protein signal transduction |
51 |
1.7E-15 |
|
| (GO:0007010) cytoskeleton organization |
129 |
1.3E-15 |
|
| (GO:0030029) actin filament-based process |
85 |
2.3E-14 |
|
| (GO:0007018) microtubule-based movement |
51 |
2.1E-12 |
|
| (GO:0016568) chromatin modification |
89 |
1.9E-12 |
|
| |
(GO:0051276) chromosome organization |
132 |
1.4E-12 |
|
GO Molecular Function |
(GO:0030554) adenyl nucleotide binding |
451 |
9.9E-59 |
| (GO:0005524) ATP binding |
433 |
2.2E-59 |
|
| (GO:0032559) adenyl ribonucleotide binding |
437 |
2.0E-59 |
|
| (GO:0001882) nucleoside binding |
456 |
6.3E-58 |
|
| (GO:0001883) purine nucleoside binding |
451 |
1.5E-56 |
|
| (GO:0017076) purine nucleotide binding |
480 |
5.2E-44 |
|
| (GO:0032555) purine ribonucleotide binding |
466 |
2.9E-44 |
|
| (GO:0032553) ribonucleotide binding |
466 |
2.9E-44 |
|
| (GO:0000166) nucleotide binding |
523 |
7.4E-39 |
|
| (GO:0003774) motor activity | 86 | 1.3E-34 |
1Gene Count: number of genes that have significant alternative exon usage within category.
2FDR-adjusted P-value: False discovery rate adjusted P-value of the hypergeometric test of category enrichment.