Table 4.
Top 5 multi-exon genes that have significant exon-independent association with glioblastoma multiforme survival
| Gene Symbol | Estimate1 | SE2 | Fold Change3 | P-value4 | P-value AEU5 | Exon Count6 | Literature7 |
|---|---|---|---|---|---|---|---|
|
Sirt2 |
0.0337 |
0.0092 |
1.0236 |
3.2E-04 |
2.5E-03 |
17 |
[62]G |
|
Six1 |
0.0056 |
0.0015 |
1.0039 |
3.3E-04 |
2.7E-01 |
5 |
[63]C |
|
Loc100289627 |
0.0079 |
0.0022 |
1.0055 |
3.8E-04 |
4.3E-01 |
2 |
NA |
|
Sema3e |
−0.0256 |
0.0066 |
0.9824 |
1.3E-04 |
2.4E-03 |
18 |
[64]C |
| Golga8j | −0.0536 | 0.0141 | 0.9635 | 1.7E-04 | 1.1E-03 | 20 | [65]C |
1Estimate: change in average exon expression per additional survival month (in log2 units).
2SE: standard error of the estimate.
3Fold change: fold change in average exon expression per additional survival month.
4P-value: unadjusted P-value of the change in average exon expression per additional survival month.
5P-value AEU: non-significant (P-value > 1.0E-03) evidence of alternative exon usage.
6Exon Count: number of exons in the gene.
7Literature: review of studies that reported associations of the gene with cancers:
G: reported association of gene with glioblastoma multiforme,
C: reported association of gene with cancer other than glioblastoma multiforme,
NA: not available.