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. Author manuscript; available in PMC: 2013 Jun 28.
Published in final edited form as: Pharmacology. 2012 Jun 28;90(1-2):55–65. doi: 10.1159/000339076

Figure 1. Effect of the atypical cannabinoid O-1602 on the longitudinal tissue preparations of mouse colon.

Figure 1

A) Representative tracing showing that O-1602 (100nM to 30μM) concentration dependently inhibited the neurogenic contractions (Electrical field –induced) in the distal colon and B) Ethanol alone, even at the maximum final concentration of 0.105%, did not affect the electrical field –induced contractions; C) Representative tracing demonstrates that the EFS- induced contractions were neurogenic as a selective CB1 agonist, WIN 55212-2 completely inhibited the contractions potently at 10 nmol/l concentration; D) Concentration –response (inhibition of EFS-evoked contractions) curve of O-1602; E) Colonic tissue -precontracted by high K+ (80 mM) was not relaxed by O-1602 suggesting no direct effect on depolarization – induced contraction of smooth muscle; F) Effect of ethanol (0.1%) alone (left), O-1602 (10 μM) (middle) on exogenous acetylcholine –induced contractions and the corresponding bar graph (right), data analyzed by repeated measures one way – ANOVA, n=3.