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. Author manuscript; available in PMC: 2013 Jun 28.
Published in final edited form as: Pharmacology. 2012 Jun 28;90(1-2):55–65. doi: 10.1159/000339076

Figure 4. Effect of JWH015, a CB2/GPR55 agonist, on neurogenic contractions in ileum from knock-out mice.

Figure 4

Representative tracings that demonstrate the inhibitory effect over neurogenic contractions in mouse colon from GPR55−/− knock-out mice(A) and lack of effect of cannabidiol (1 μM), considered to be a GPR55 antagonist, on EFS-contractions of ileum from wild type mice(B). Bottom panel represents comparison of concentration – response curves of JWH015 in C) wild type control (open squares) vs wild type-in the presence of cannabidiol(filled circles) and D) wild type (open squares) vs GPR55−/− (filled circles) mice. The concentration –response curves were subjected to non –linear regression for calculation of pD2 values. Each data point represents mean ± SE, analyzed by two-way ANOVA followed by Bonferroni’s posttest, n=3-5.