A) Concentration –dependent response curves of JWH015, a CB2/GPR55 agonist, on neurogenic contraction inhibition in ileum from wild type (open squares) vs CB1−/−/CB2−/− double knock out (filled squares) mice. B) Effect of JWH015 on exogenous acetylcholine –induced contractions of ileum from wild type mice: control (open squares) vs in the presence of JWH015 (3 μmol/l) (filled squares) . Each data point represents mean ± SE, analyzed by two-way ANOVA followed by Bonferroni’s posttest, n=3. *P<0.05, ***P<0.001 considered significant vs control (in the absence of JWH015).