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. Author manuscript; available in PMC: 2014 Jan 15.
Published in final edited form as: Cancer Res. 2012 Nov 30;73(2):496–501. doi: 10.1158/0008-5472.CAN-12-2852

Figure 1.

Figure 1

IDH1R132H/− gliomas have lower D-2HG than IDH1R132H/WT gliomas. A, Two anaplastic astrocytomas WHO grade III (A3) which progressed to glioblastomas WHO grade IV (sGBM) demonstrate loss of the wild type IDH1 allele and decreased levels of D-2HG. Mutant IDH1R132H is CAT (His); wild type IDH1 is CGT (Arg). B, D-2HG levels in human gliomas with wild type IDH1 (WT/WT), heterozygous IDH1 mutation (R132H/WT), or IDH1 mutation with loss of wild type IDH1 (R132H/−). LGG, lower grade glioma WHO grade II or III.