Table 3.
Characteristics of a healthy phenotype | Moderate | Severe | ||||
---|---|---|---|---|---|---|
TGFβ3+Dex | CTGF | Link-N | TGFβ3+Dex | CTGF | Link-N | |
Proliferative capability | ++ | ++ | ++ | + | − | − |
High metabolic rate | ++ | ++ | ++ | ++ | − | − |
GAG rich matrix | ++ | ++ | ++ | ++ | ++ | ++ |
High ACAN/COL2A1 ratio | ++ | ++ | ++ | + | − | − |
Low MMP9 expression | − | + | + | − | ++ | ++ |
Low Il1β expression | − | + | + | − | ++ | ++ |
TGFβR1 expression | ++ | ++ | ++ | + | − | − |
Qualitative grading: ++ highest increase, + moderate increase, − negligible increase or smallest effect
Italics indicates no differences were observed between groups.
indicates an assay where a negligible increase or small effect demonstrates an effective stimulus.