Table 1.
Cell Line | MK-8776 + SN38 | MK-1775 + SN38 | MK-8776 + MK1775 | MK-8776 + Gemcitabine | MK-1775 + Gemcitabine |
---|---|---|---|---|---|
IMR-5 | ± | + | +++++ | +++ | +++++ |
BE2C | ± | +++ | ++ | ++++ | +++ |
NB1 | ++ | −− | −− | +++ | −−− |
Ebc1 | +++++ | ± | +++++ | +++++ | ++++ |
NBSD | +++ | ++++ | +++ | +++++ | ± |
Kelly | +++++ | +++++ | ++ | ++++ | +++++ |
NGP | ++++ | +++ | ++++ | +++++ | +++++ |
SKNAS | ++++ | +++++ | +++ | +++++ | +++++ |
NLF | ++++ | +++ | ++++ | +++++ | − |
NB-1643 | +++ | +++ | +++++ | +++++ | +++++ |
CI Value | Symbol | Observed Synergy |
---|---|---|
<0.1 | +++++ | very strong |
0.1–0.3 | ++++ | strong |
0.3–0.7 | +++ | synergy |
0.7–0.85 | ++ | moderate synergism |
0.85–0.9 | + | slight synergism |
0.9–1.1 | ± | additive |
>1.1 | − | antagonistic |