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Association between CYP2D6 phenotype and disease event during the 5 years of drug therapy in arms A and B
| Tamoxifen only (Arm A) | Tamoxifen followed by anastrozole (Arm B) | |||
|---|---|---|---|---|
| Odds Ratio (95% CI) | p-value | Odds Ratio (95% CI) | p-value | |
| PM/PM relative to EM/EM | 2.45 (1.05, 5.73) | 0.04 | 0.60 (0.15, 2.37) | 0.47 |
| EM/PM and PM/IM relative to EM/EM | 1.67 (0.95, 2.93) | 0.07 | 0.76 (0.43, 1.31) | 0.32 |
| EM/IM and IM/IM relative to EM/EM | 1.23 (0.58, 2.61) | 0.60 | 1.02 (0.52, 2.01) | 0.96 |
