Table 4.
Unadjusted and adjusted odds ratios for the associations between adherence items and detectable HIV viral load and CD4+cell counts using GEE analyses.
| Detectable viral load | CD4+ cell count < 200 cells/mm3 | |||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Unadjusted | Adjusted | Unadjusted | Adjusted | |||||
|
| ||||||||
| OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |
| SRSI-5 cat | ||||||||
| Excellent | 1 | 1 | 1 | 1 | ||||
| Very Good | 1.7 (1.4 – 2.2) | < 0.001 | 1.7 (1.4 – 2.2) | < 0.001 | 1.7 (1.4 – 2.2) | < 0.001 | 1.7 (1.3 – 2.2) | < 0.001 |
| Good | 3.4 (2.6 – 4.4) | < 0.001 | 3.1 (2.4 – 4.0) | < 0.001 | 2.4 (1.8 – 3.2) | < 0.001 | 2.2 (1.7 – 3.0) | < 0.001 |
| Fair | 5.7 (4.0 – 8.1) | < 0.001 | 5.0 (3.5 – 7.2) | < 0.001 | 4.4 (2.9 – 6.5) | < 0.001 | 3.9 (2.6 – 5.9) | < 0.001 |
| Poor/Very Poor | 11.0 (7.1 – 17.0) | < 0.001 | 9.7 (6.2 – 15.1) | < 0.001 | 4.1 (2.6 – 6.6) | < 0.001 | 3.5 (2.2 – 5.5) | < 0.001 |
| Last 4 Days | ||||||||
| None | 1 | 1 | 1 | 1 | ||||
| One | 1.5 (1.2 – 2.0) | 0.002 | 1.4 (1.1 – 1.9) | 0.008 | 1.2 (1.0 – 1.6) | 0.1 | 1.2 (0.9 – 1.6) | 0.2 |
| Two | 2.8 (2.0 – 4.0) | < 0.001 | 2.5 (1.7 – 3.5) | < 0.001 | 2.1 (1.4 – 3.0) | < 0.001 | 1.7 (1.2 – 2.5) | < 0.003 |
| Three | 3.7 (2.2 – 6.3) | < 0.001 | 3.0 (1.8–5.1) | < 0.001 | 2.4 (1.4–4.3) | 0.003 | 2.1 (1.1–3.8) | 0.02 |
| Four | 5.9 (3.5 – 10.1) | < 0.001 | 5.5 (3.2–9.3) | < 0.001 | 1.8 (0.9–3.5) | 0.1 | 1.5 (0.8–3.1) | 0.2 |
| > Four | 10.4 (6.3 – 17.2) | < 0.001 | 9.2 (5.4–15.4) | < 0.001 | 3.5 (2.1–6.0) | < 0.001 | 2.7 (1.6–4.7) | < 0.001 |
| Last Weekend | ||||||||
| No | 1 | 1 | 1 | 1 | ||||
| Yes | 1.5 (1.2 – 2.0) | < 0.001 | 2.5 (2.0 – 3.2) | < 0.001 | 2.0 (1.5 – 2.6) | < 0.001 | 1.8 (1.4–2.4) | < 0.001 |
| Last Missed Dose | ||||||||
| Never Skip Meds | 1 | 1 | 1 | 1 | ||||
| > 3 Months Ago | 0.9 (0.7 – 1.3) | 0.7 | 1.0 (0.7 – 1.4) | 1.0 | 0.9 (0.7 – 1.3) | 0.7 | 1.0 (0.7 – 1.4) | 0.9 |
| 1 – 3 Months Ago | 0.9 (0.6 – 1.2) | 0.4 | 0.9 (0.7 – 1.3) | 0.6 | 0.8 (0.6 – 1.1) | 0.2 | 0.8 (0.6 – 1.2) | 0.3 |
| 2 – 4 Weeks Ago | 1.0 (0.7 – 1.4) | 0.9 | 1.1 (0.8 – 1.5) | 0.6 | 1.2 (0.8 – 1.6) | 0.4 | 1.2 (0.9 – 1.7) | 0.2 |
| 1 – 2 Weeks Ago | 1.7 (1.3 – 2.3) | < 0.001 | 1.8 (1.3 – 2.4) | < 0.001 | 1.5 (1.1 – 2.0) | 0.009 | 1.6 (1.2 – 2.1) | 0.004 |
| Within Past Week | 1.8 (1.4 – 2.3) | < 0.001 | 1.8 (1.4 – 2.3) | < 0.001 | 1.4 (1.0 – 1.8) | 0.03 | 1.3 (1.0 – 1.8) | 0.05 |
| VAS | ||||||||
| 100% | 1 | 1 | 1 | 1 | ||||
| 95 – 99% | 1.4 (1.1 – 1.8) | 0.002 | 1.5 (1.2 – 1.9) | 0.002 | 1.1 (0.9 – 1.4) | 0.5 | 1.1 (0.9 – 1.4) | 0.4 |
| 90 – 94% | 2.1 (1.6 – 2.9) | < 0.001 | 2.0 (1.5 – 2.8) | < 0.001 | 1.6 (1.1 – 2.2) | 0.009 | 1.5 (1.1 – 2.1) | 0.015 |
| < 90% | 4.4 (3.4 – 5.8) | < 0.001 | 4.1 (3.1 – 5.4) | < 0.001 | 2.7 (2.0 – 3.7) | < 0.001 | 2.5 (1.8 – 3.4) | < 0.001 |
Note. SRSI-5 cat = self-rating scale item with the bottom two categories combined; VAS = visual analogue scale; Last 4 Days = “How many doses of your medications did you miss in the last 4 days?”; Last Weekend = “Did you miss any of your medication last weekend…?; Last Missed Dose = “When was the last time you missed any of your medications?” Adjusted analyses included patients’ sex, age, race, and HIV-transmission risk factor as covariates.