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. Author manuscript; available in PMC: 2014 Jan 15.
Published in final edited form as: Cancer Res. 2012 Nov 1;73(2):716–724. doi: 10.1158/0008-5472.CAN-12-2784

Figure 1.

Figure 1

Computational predicted binding mode of HOI-07 with Aurora B and the cytotoxicity of HOI-07. A, chemical structure of HOI-07. B, computational predicted binding mode of HOI-07 with Aurora B. Left: HOI-07 is docked, using Glide, into the binding pocket of Aurora B. Aurora B is shown as light blue cartoon and HOI-07 is shown as sticks. Right: Interaction between HOI-07 and Aurora B. HOI-07 forms a hydrogen bond with Ala173. C and D, cytotoxicity of HOI07 on MRC-5 normal lung cells (C) and A549 lung cancer cells (D). No obvious cytotoxicity by HOI-07 was observed in eitherMRC-5 and A549 cells at concentrations below 1 µM.