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. Author manuscript; available in PMC: 2014 Feb 25.
Published in final edited form as: Neurobiol Dis. 2012 Aug 25;0:49–56. doi: 10.1016/j.nbd.2012.08.010

FIGURE 4. Upregulating Hsp70 ameliorates toxicity induced by proteasome inhibition.

FIGURE 4

Transiently transfected CHO cells were treated at 24 hours post transfection with: DMSO (veh); 2.5 μM MG-132 for 24 hours;10 μM geldanamycin (Gel) for 24 hours; 2.5 μM MG-132 for 48 hours; or 2.5 μM MG-132 for 48 hours with the cells simultaneously being exposed to 10 μM geldanamycin for the last 24 hours. Values represent the means of 3 independent experiments, ± SEM. Statistical analysis was based on comparisons of cell death in the MG48 condition vs. the MG48 + Gel24h condition for each mutant (*=p<0.05, **=p<0.01, ***=p<0.001).