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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Dev Biol. 2012 Nov 17;374(1):198–209. doi: 10.1016/j.ydbio.2012.11.007

Figure 6. Summary model of direct and indirect autoregulation of Nkx2.5 SHF enhancers.

Figure 6

Annotated model shows models of early activation of both mouse/mammalian 5’ Nkx2.5 and Chick/non-mammalian 3’ SHF enhancers by BMP via Gata, Smad and YY1 mediated mechanisms during early cardiac induction in SHF progenitors and later maintenance of expression in cardiac myocytes of the aortic pole. Mouse/mammalian enhancer expression is maintained during cardiac differentiation in part through recruitment of Nkx2.5 by protein-protein interaction with Mef2c in emerging heart cells (left). In chick and other avian or non-mammalian species SHF expression is maintained by direct recruitment of Nkx2.5 to consensus enhancer binding sites. Model incorporates both findings in this work and referenced findings from previous studies.