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. 2013 Feb;20(2):109–119. doi: 10.1101/lm.029157.112

Figure 4.

Figure 4.

Intra-LA infusion of an inhibitor of p300/CBP activity impairs the reconsolidation of a “well-consolidated” fear memory. (A) Rats were fear-conditioned with three tone–shock pairings. Two weeks following training, rats were given a memory reactivation session consisting of a single-tone CS presentation followed 1 h later by intra-LA infusion of Vehicle (n = 5) or c646 (500 ng/side; n = 6). (B) Memory retrieval data for the Vehicle- and c646-infused groups. (*) P < 0.05 relative to the pre-CS period. (C) Mean (±SEM) percent freezing during the PR-STM and PR-LTM tests in Vehicle- and c646-infused rats. (D) Cannula placements for rats infused with either Vehicle (black circles) or c646 (gray circles). (*) P < 0.05 relative to Vehicle-infused controls.