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. 2013 Feb;20(2):109–119. doi: 10.1101/lm.029157.112

Figure 5.

Figure 5.

Intra-LA infusion of an inhibitor of p300/CBP activity impairs fear memory consolidation and the consolidation of training-related neural plasticity in the LA. (A) Rats were given two baseline AEFP recording sessions on separate days followed by fear conditioning with three tone-pip–shock pairings followed 1 h later by intra-LA infusion of either Vehicle (n = 8) or c646 (500 ng/side; n = 7). Rats in each group were then tested for STM and LTM 3 and 21 h later while AEFPs were recorded from the LA. (B) Mean (±SEM) percent freezing during the STM and LTM tests in Vehicle- and c646-infused groups. (C) Mean (±SEM) percent of change in AEFP amplitude during the STM and LTM tests in Vehicle- and c646-infused rats, relative to baseline. (*) P < 0.05 relative to Vehicle-infused controls. (D) Representative AEFPs recorded from the LA for each group during baseline (light gray trace), STM and LTM sessions (darker traces). Scale bar, 10 µV, 5 msec. (E) Electrode placements for rats infused with either Vehicle (black circles) or c646 (gray circles).