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. 2013 Feb;20(2):109–119. doi: 10.1101/lm.029157.112

Figure 6.

Figure 6.

Intra-LA infusion of an inhibitor of p300/CBP activity impairs fear memory reconsolidation and memory-related neural plasticity in the LA. (A) Rats were given two baseline AEFP recording sessions on separate days followed by fear conditioning with three tone-pip–shock pairings. Twenty-four hours following training, rats were given a memory reactivation session consisting of a single tone-pip CS presentation followed 1 h later by intra-LA infusions of Vehicle (n = 5) or c646 (500 ng/side; n = 6). Rats in each group were then tested for PR-STM and PR-LTM 3 and 21 h later while AEFPs were recorded from the LA. (B) Memory retrieval data for the Vehicle- and c646-infused groups. (*) P < 0.05 relative to the pre-CS period. (C) Mean (±SEM) percent freezing during the PR-STM and PR-LTM tests in Vehicle- and c646-infused groups. (D) Mean (±SEM) percent of change in AEFP amplitude during the PR-STM and PR-LTM tests in Vehicle- and c646l-infused rats, relative to baseline. (*) P < 0.05 relative to Vehicle-infused controls. (E) Representative AEFPs recorded from the LA for each group during baseline (light gray trace), PR-STM and PR-LTM sessions (darker traces). Scale bar, 10 µV, 5 msec. (F) Electrode placements for rats infused with either Vehicle (black circles) or c646 (gray circles).