Fig. 2.

Comparison of CRM1 conformations in different crystal structures. Free ctCRM1 (A), CRM1–RanGTP–SPN1 (B), CRM1–SPN1 (C), and CRM1–RanGTP–RanBP1 (D) are shown. CRM1 is depicted as rainbow colored surface from N (blue) to C terminus (red), whereas the interacting proteins are shown as tube models (SPN1, purple; RanGTP, beige; RanBP1, red). The position of the NES cleft in structures lacking cargo is marked by a black arrowhead. The bars at the side of the individual structures indicate the dimension of the protein in the shown orientation.