Fig. 5.

MD simulations of WT and mutant free ctCRM1. Projections of WT simulations (A, cyan) and simulations with deleted C-terminal helix (B, red) onto the difference vector between the extended and compact structure constitute a measure of how much the protein changes into the compact conformation. (C) Projections onto the plane in the configurational space spanned by the extended, compact, and almost compact crystal structure show that, after deletion of the C-terminal helix, the system adopts the configuration of the almost compact structure (magenta square) rather than the compact conformation (orange square).