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Model for cooperative CRM1 export complex assembly and disassembly showing its conformational variability and the important structural features in different states of the transport cycle. CRM1 is shown in the respective conformations and colored in gray with the acidic loop highlighted in green. The C-terminal helix of CRM1 is shown in red, and the NES binding cleft is represented by blue ovals. The PDB ID codes of the individual crystal structures used are indicated.
